Version 5.4
Homo sapiens Gene: TPST1
Summary
InnateDB Gene IDBG-18615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPST1
Gene Name tyrosylprotein sulfotransferase 1
Synonyms TANGO13A
Species Homo sapiens
Ensembl Gene ENSG00000169902
Encoded Proteins
IDBP-18617
tyrosylprotein sulfotransferase 1
IDBP-376822
tyrosylprotein sulfotransferase 1
IDBP-376824
tyrosylprotein sulfotransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21665277
TPST1 silencing reduces the IL6 production in LPS-stimulated macrophages. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21665277
[Mus musculus] Tpst1 silencing reduces the Il6 production in LPS-stimulated macrophages.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:66205199-66420543
Strand Forward strand
Band q11.21
Transcripts
ENST00000304842 ENSP00000302413
ENST00000442120 ENSP00000399642
ENST00000451388 ENSP00000391338
ENST00000480281
ENST00000490159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation
GO:0006954 inflammatory response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034118
View Gene Order
ENSBTAG00000000390
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.421194
RefSeq NM_003596
HUGO
OMIM
CCDS CCDS5533
HPRD 07216
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca