Version 5.4
Mus musculus Gene: Mycbp
Summary
InnateDB Gene IDBG-186376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mycbp
Gene Name c-myc binding protein
Synonyms 5730488M09Rik; Amy-1; AW552132; AW742590
Species Mus musculus
Ensembl Gene ENSMUSG00000028647
Encoded Proteins
IDBP-186378
c-myc binding protein
IDBP-269261
c-myc binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000214114:
This locus represents naturally occurring read-through transcription between the neighboring GJA9 (gap junction protein, alpha 9, 59kDa) and MYCBP (c-myc binding protein) genes on chromosome 1. Alternative splicing results in multiple transcript variants. These variants are either candidates for nonsense-mediated mRNA decay (NMD) and/or they lack a significant open reading frame, thus they are unlikely to produce protein products. [provided by RefSeq, Dec 2010] The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:123904832-123912269
Strand Forward strand
Band D2.2
Transcripts
ENSMUST00000030400 ENSMUSP00000030400
ENSMUST00000106202 ENSMUSP00000101808
ENSMUST00000147340
ENSMUST00000137685
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000214114
View Gene Order
ENSBTAG00000030337
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.446162
RefSeq NM_019660
OMIM
CCDS CCDS18621
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca