Version 5.4
Mus musculus Gene: Brdt
Summary
InnateDB Gene IDBG-186768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brdt
Gene Name bromodomain, testis-specific
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029279
Encoded Proteins
IDBP-186770
bromodomain, testis-specific
IDBP-255506
bromodomain, testis-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:107331159-107387058
Strand Forward strand
Band E5
Transcripts
ENSMUST00000031215 ENSMUSP00000031215
ENSMUST00000112677 ENSMUSP00000108297
ENSMUST00000161377
ENSMUST00000162804
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042393 histone binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0001207 histone displacement
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0007140 male meiosis
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0008380 RNA splicing
GO:0030154 cell differentiation
GO:0043484 regulation of RNA splicing
GO:0051039 positive regulation of transcription during meiosis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137948
View Gene Order
ENSBTAG00000047443
Not yet available
Cross-References
SwissProt Q91Y44
TrEMBL Q8BNZ8
UniProt Splice Variant
Entrez Gene 114642
UniGene Mm.182836 Mm.475506
RefSeq NM_054054 XM_006534728 XM_006534729 XM_006534730 NM_001079873
OMIM
CCDS CCDS19500 CCDS39197
HPRD
IMGT
MGI ID MGI:1891374
MGI Symbol Brdt
EMBL AB208640 AC126598 AF358660 AK078663 CH466529
GenPept AAK50736 BAC37352 BAD91553 EDL20168
RNA Seq Atlas 114642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca