InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cbfb

Summary

InnateDB Gene

IDBG-186824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbfb

Gene Name

core binding factor beta

Synonyms

AI893578; PEA2; Pebp2; PEBP2b; Pebpb2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031885

Encoded Proteins

IDBP-186826

core binding factor beta

IDBP-262486

core binding factor beta

IDBP-262488

core binding factor beta

IDBP-262490

core binding factor beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067955:
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:105170674-105217989

Strand

Forward strand

Band

Transcripts

ENSMUST00000052209	ENSMUSP00000059382
ENSMUST00000109395	ENSMUSP00000105022
ENSMUST00000109394	ENSMUSP00000105021
ENSMUST00000109392	ENSMUSP00000105019
ENSMUST00000186070
ENSMUST00000190915
ENSMUST00000187323

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0030098	lymphocyte differentiation
GO:0030099	myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0060216	definitive hemopoiesis

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000067955

View Gene Order

ENSBTAG00000016103

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

atf2_pathway

ATF-2 transcription factor network

ap1_pathway

AP-1 transcription factor network

smad2_3nuclearpathway

Regulation of nuclear SMAD2/3 signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2018 Mm.399600

RefSeq

NM_001161456 NM_001161457 NM_001161458 NM_022309 XM_006530622

OMIM

CCDS

CCDS22592 CCDS52654 CCDS52655 CCDS52656

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas