InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tradd

Summary

InnateDB Gene

IDBG-186918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tradd

Gene Name

TNFRSF1A-associated via death domain

Synonyms

9130005N23Rik; AA930854

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031887

Encoded Proteins

IDBP-186920

TNFRSF1A-associated via death domain

IDBP-537721

TNFRSF1A-associated via death domain

IDBP-542491

TNFRSF1A-associated via death domain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18439848

[Homo sapiens] TRADD is recruited to MAVS and orchestrated complex formation with TRAF3 and TANK and with FADD and RIPK1, leading to the activation of IRF3 and NF-kappaB-TRADD is not only essential in TNFR1 signalling but also in RIG-I antiviral pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102871:
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:105258286-105264609

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034359	ENSMUSP00000034359
ENSMUST00000136239
ENSMUST00000144762	ENSMUSP00000119174
ENSMUST00000147670	ENSMUSP00000115535

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 81 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	81 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0060090	binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051291	protein heterooligomerization
GO:0051798	positive regulation of hair follicle development
GO:0097191	extrinsic apoptotic signaling pathway