Version 5.4
Mus musculus Gene: Fbxl8
Summary
InnateDB Gene IDBG-186963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl8
Gene Name F-box and leucine-rich repeat protein 8
Synonyms FBL8
Species Mus musculus
Ensembl Gene ENSMUSG00000033313
Encoded Proteins
IDBP-186965
F-box and leucine-rich repeat protein 8
IDBP-538772
F-box and leucine-rich repeat protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135722:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105264648-105269326
Strand Forward strand
Band D3
Transcripts
ENSMUST00000036221 ENSMUSP00000038638
ENSMUST00000126923 ENSMUSP00000115366
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135722
View Gene Order
ENSBTAG00000023632
Not yet available
Cross-References
SwissProt Q8CIG9
TrEMBL D6RGN0 Q3TD55
UniProt Splice Variant
Entrez Gene 50788
UniGene Mm.334764
RefSeq NM_015821
OMIM
CCDS CCDS22595
HPRD
IMGT
MGI ID MGI:1354697
MGI Symbol Fbxl8
EMBL AC124584 AF176523 AK155194 AK170367 BC023902 CH466525
GenPept AAF09132 AAH23902 BAE33108 BAE41749 EDL11257
RNA Seq Atlas 50788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca