InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myh3

Summary

InnateDB Gene

IDBG-187090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh3

Gene Name

myosin, heavy polypeptide 3, skeletal muscle, embryonic

Synonyms

MyHC-emb; Myhs-e; Myhse

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020908

Encoded Proteins

IDBP-187092

myosin, heavy polypeptide 3, skeletal muscle, embryonic

IDBP-264002

myosin, heavy polypeptide 3, skeletal muscle, embryonic

IDBP-626339

myosin, heavy polypeptide 3, skeletal muscle, embryonic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109063:
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67078300-67102291

Strand

Forward strand

Band

Transcripts

ENSMUST00000007301	ENSMUSP00000007301
ENSMUST00000108689	ENSMUSP00000104329
ENSMUST00000165221	ENSMUSP00000131883

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0051015	actin filament binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006200	ATP catabolic process
GO:0008152	metabolic process

Cellular Component

GO:0016459	myosin complex
GO:0030016	myofibril
GO:0032982	myosin filament
GO:0043292	contractile fiber
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000109063

View Gene Order

ENSBTAG00000011803

Not yet available

Pathways

NETPATH

REACTOME

REACT_232053

Striated Muscle Contraction pathway

REACT_262759

Muscle contraction pathway

KEGG

mmu04530

Tight junction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_16969

Striated Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04530

Tight junction pathway

INOH

PID NCI

Cross-References

SwissProt

P13541

TrEMBL

Q1WNQ4

UniProt Splice Variant

Entrez Gene

17883

UniGene

Mm.340090

RefSeq

NM_001099635 XM_006532412

OMIM

CCDS

CCDS36184

HPRD

IMGT

MGI ID

MGI:1339709

MGI Symbol

Myh3

EMBL

AK132623 AL596129 AL645988 AY963798 DQ021874 DQ021875 M11154

GenPept

AAA39791 AAY42744 AAY42755 AAY42756 BAE21268 CAI24992 CAI25982

RNA Seq Atlas

17883