InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myh2

Summary

InnateDB Gene

IDBG-187156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh2

Gene Name

myosin, heavy polypeptide 2, skeletal muscle, adult

Synonyms

MHC2A; Myh2a; MyHC-IIa; Myhs-f; Myhs-f1; Myhsf1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033196

Encoded Proteins

IDBP-187160

myosin, heavy polypeptide 2, skeletal muscle, adult

IDBP-626400

myosin, heavy polypeptide 2, skeletal muscle, adult

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125414:
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67171027-67197517

Strand

Forward strand

Band

Transcripts

ENSMUST00000018641	ENSMUSP00000018641
ENSMUST00000124337
ENSMUST00000170159	ENSMUSP00000129544

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001778	plasma membrane repair
GO:0006412	translation
GO:0008152	metabolic process
GO:0014823	response to activity
GO:0016192	vesicle-mediated transport
GO:0070252	actin-mediated cell contraction

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005826	actomyosin contractile ring
GO:0005840	ribosome
GO:0005859	muscle myosin complex
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0031672	A band
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000125414

View Gene Order

ENSBTAG00000007090

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04530

Tight junction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160086

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04530

Tight junction pathway

INOH

PID NCI

integrin_a4b1_pathway

Alpha4 beta1 integrin signaling events

amb2_neutrophils_pathway

amb2 Integrin signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.422801

RefSeq

NM_001039545 XM_006532411

OMIM

CCDS

CCDS24854

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas