Version 5.4
Mus musculus Gene: Ube2n
Summary
InnateDB Gene IDBG-187167.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2n
Gene Name ubiquitin-conjugating enzyme E2N
Synonyms 1500026J17Rik; AL022654; BB101821; UBC13
Species Mus musculus
Ensembl Gene ENSMUSG00000074781
Encoded Proteins
IDBP-187169
ubiquitin-conjugating enzyme E2N
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16862162
[Homo sapiens] UBE2N abalation resulted in defective B cell development and in impaired B cell and macrophage activation.
PMID 26101372
[Homo sapiens] TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177889:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:95515162-95545658
Strand Forward strand
Band C2
Transcripts
ENSMUST00000099329 ENSMUSP00000096932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 114 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0043130 ubiquitin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0006301 postreplication repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0016574 histone ubiquitination
GO:0031058 positive regulation of histone modification
GO:0033182 regulation of histone ubiquitination
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045739 positive regulation of DNA repair
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0070534 protein K63-linked ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031372 UBC13-MMS2 complex
GO:0035370 UBC13-UEV1A complex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177889
View Gene Order
ENSBTAG00000021767
Not yet available
Pathways
NETPATH
REACTOME
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_225145
Downstream TCR signaling pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_205561
FCERI mediated NF-kB activation pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_198535
Antiviral mechanism by IFN-stimulated genes pathway
REACT_198533
ISG15 antiviral mechanism pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_198527
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_198666
Interferon Signaling pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_261687
Signaling by Interleukins pathway
REACT_211125
NOD1/2 Signaling Pathway pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_229531
Adaptive Immune System pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_224208
Interleukin-1 signaling pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_222648
TCR signaling pathway
REACT_198546
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
REACT_198543
IRAK1 recruits IKK complex pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
B cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_13
IL1 pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_24918
IRAK1 recruits IKK complex pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25120
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_25354
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_12555
Downstream TCR signaling pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_12526
TCR signaling pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_25229
Interferon Signaling pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_224941
NOD1/2 Signaling Pathway pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_215264
ISG15 antiviral mechanism pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210227
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_205423
Downstream TCR signaling pathway
REACT_213138
Immune System pathway
REACT_224319
Antiviral mechanism by IFN-stimulated genes pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_219947
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_225103
Interferon Signaling pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_219042
FCERI mediated NF-kB activation pathway
REACT_227483
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
REACT_214469
Adaptive Immune System pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_216714
Innate Immune System pathway
REACT_207826
Interleukin-1 signaling pathway
REACT_206833
Signaling by Interleukins pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_225194
IRAK1 recruits IKK complex pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
REACT_213465
TCR signaling pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
B cell receptor signaling pathway
PID NCI
il1pathway
IL1-mediated signaling events
atm_pathway
ATM pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.372849 Mm.397507 Mm.403043 Mm.470162 Mm.486592
RefSeq NM_080560 XM_006514344
OMIM
CCDS CCDS48677
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca