Version 5.4
Mus musculus Gene: Nudt4
Summary
InnateDB Gene IDBG-187188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nudt4
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 4
Synonyms 4933436C10Rik; DIPP2; DIPP2alpha; DIPP2beta; HDCMB47P
Species Mus musculus
Ensembl Gene ENSMUSG00000020029
Encoded Proteins
IDBP-187190
nudix (nucleoside diphosphate linked moiety X)-type motif 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173598:
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:95547007-95564167
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000020217 ENSMUSP00000020217
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity
GO:0016787 hydrolase activity
GO:0030515 snoRNA binding
GO:0046872 metal ion binding
GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052843 inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052844 inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052846 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000173598
View Gene Order
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_196482
Synthesis of pyrophosphates in the cytosol pathway
REACT_196476
Inositol phosphate metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150188
Synthesis of pyrophosphates in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8R2U6
TrEMBL Q4FJR0
UniProt Splice Variant
Entrez Gene 71207
UniGene Mm.24397 Mm.444833 Mm.467693 Mm.471760
RefSeq NM_027722 XM_006514116
OMIM
CCDS CCDS24138
HPRD
IMGT
MGI ID MGI:1918457
MGI Symbol Nudt4
EMBL AK017075 AK048062 BC027209 CH466539 CT010342
GenPept AAH27209 BAB30582 BAC33229 CAJ18550 EDL21611
RNA Seq Atlas 71207

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca