Mus musculus Gene: Gli2
InnateDB Gene IDBG-187317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gli2
Gene Name GLI-Kruppel family member GLI2
Synonyms AW546128;
Species Mus musculus
Ensembl Gene ENSMUSG00000048402
Encoded Proteins
GLI-Kruppel family member GLI2
GLI-Kruppel family member GLI2
GLI-Kruppel family member GLI2
GLI-Kruppel family member GLI2
GLI-Kruppel family member GLI2
GLI-Kruppel family member GLI2
GLI-Kruppel family member GLI2
GLI-Kruppel family member GLI2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074047:
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:118834132-119053619
Strand Reverse strand
Band E2.3
ENSMUST00000062483 ENSMUSP00000054837
ENSMUST00000161301 ENSMUSP00000125342
ENSMUST00000162552 ENSMUSP00000125059
ENSMUST00000161056 ENSMUSP00000124768
ENSMUST00000160991 ENSMUSP00000125634
ENSMUST00000159839 ENSMUSP00000125661
ENSMUST00000161451 ENSMUSP00000124132
ENSMUST00000162607 ENSMUSP00000123808
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0002009 morphogenesis of an epithelium
GO:0002062 chondrocyte differentiation
GO:0002076 osteoblast development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007224 smoothened signaling pathway
GO:0007389 pattern specification process
GO:0007411 axon guidance
GO:0007418 ventral midline development
GO:0007442 hindgut morphogenesis
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008589 regulation of smoothened signaling pathway
GO:0009612 response to mechanical stimulus
GO:0009913 epidermal cell differentiation
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0021508 floor plate formation
GO:0021513 spinal cord dorsal/ventral patterning
GO:0021517 ventral spinal cord development
GO:0021522 spinal cord motor neuron differentiation
GO:0021696 cerebellar cortex morphogenesis
GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021904 dorsal/ventral neural tube patterning
GO:0021915 neural tube development
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021965 spinal cord ventral commissure morphogenesis
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030879 mammary gland development
GO:0030902 hindbrain development
GO:0032331 negative regulation of chondrocyte differentiation
GO:0035295 tube development
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0045666 positive regulation of neuron differentiation
GO:0045740 positive regulation of DNA replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048566 embryonic digestive tract development
GO:0048589 developmental growth
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048666 neuron development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048856 anatomical structure development
GO:0060032 notochord regression
GO:0060322 head development
GO:0060513 prostatic bud formation
GO:0060603 mammary gland duct morphogenesis
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0071407 cellular response to organic cyclic compound
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0031512 motile primary cilium
GO:0072372 primary cilium
GO:0097542 ciliary tip
Homo sapiens
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Hedgehog 'off' state pathway
Degradation of GLI2 by the proteasome pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Hedgehog signaling pathway pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
Pathway Predictions based on Human Orthology Data
Hedgehog pathway
Signaling by Hedgehog pathway
Degradation of GLI2 by the proteasome pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Hedgehog signaling pathway pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
Hedgehog signaling pathway pathway
Signaling events mediated by the Hedgehog family
Hedgehog signaling events mediated by Gli proteins
SwissProt Q0VGT2
TrEMBL A5A9W3 A5A9W4 A5A9W5 A5AA25 A5AA26 A5AA27 F6TWE5 F6UUE3 Q8BKI7 Q8K0K3
UniProt Splice Variant
Entrez Gene 14633
UniGene Mm.273292
RefSeq NM_001081125 XM_006529140 XM_006529141
MGI ID MGI:95728
MGI Symbol Gli2
EMBL AC109271 AC122287 AC132589 AK051858 AM261668 AM261669 AM261670 AM262741 AM262742 AM262743 AM262744 BC031171 BC085190
GenPept AAH31171 AAH85190 BAC34789 CAK12555 CAK12556 CAK12557 CAK18603 CAK18604 CAK18605 CAK18609
RNA Seq Atlas 14633