InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Krt8

Summary

InnateDB Gene

IDBG-187352.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krt8

Gene Name

keratin 8

Synonyms

AA960620; AL022697; AU019895; Card2; EndoA; K8; Krt-2.8; Krt2-8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049382

Encoded Proteins

IDBP-187354

keratin 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170421:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:101996711-102004342

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023952

ENSMUSP00000023952

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0097110	scaffold protein binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0007275	multicellular organismal development
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0045214	sarcomere organization
GO:0046417	chorismate metabolic process
GO:0051599	response to hydrostatic pressure
GO:0051707	response to other organism
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097284	hepatocyte apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0005911	cell-cell junction
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016363	nuclear matrix
GO:0030018	Z disc
GO:0042383	sarcolemma
GO:0043034	costamere
GO:0045095	keratin filament
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000170421

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

p38alphabetadownstreampathway

Signaling mediated by p38-alpha and p38-beta

Cross-References

SwissProt

P11679

TrEMBL

UniProt Splice Variant

Entrez Gene

16691

UniGene

RefSeq

NM_031170

OMIM

CCDS

CCDS27868

HPRD

IMGT

MGI ID

MGI:96705

MGI Symbol

Krt8

EMBL

AK077597 AK145546 AK145679 AK145777 AK146948 AK147044 AK166737 AK166768 AK166854 AK166960 AK166993 AK167120 AK167269 AK167471 AK168522 AK168540 AK168561 AK168726 AK168910 AK169136 AK169691 BC094009 BC106154 D90360 M21836 M22831 X12789 X15662

GenPept

AAA37548 AAA37550 AAA37551 AAH94009 AAI06155 BAA14375 BAC36888 BAE26499 BAE26585 BAE26646 BAE27557 BAE27630 BAE38980 BAE39006 BAE39072 BAE39143 BAE39172 BAE39268 BAE39382 BAE39554 BAE40401 BAE40418 BAE40434 BAE40567 BAE40723 BAE40915 BAE41308 CAA31278 CAA33697

RNA Seq Atlas

16691