InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Senp6

Summary

InnateDB Gene

IDBG-187703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Senp6

Gene Name

SUMO/sentrin specific peptidase 6

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034252

Encoded Proteins

IDBP-187707

SUMO/sentrin specific peptidase 6

IDBP-625400

SUMO/sentrin specific peptidase 6

IDBP-625401

SUMO/sentrin specific peptidase 6

IDBP-742514

IDBP-741715

IDBP-742131

IDBP-742629

IDBP-742699

IDBP-741931

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112701:
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:80066903-80144953

Strand

Forward strand

Band

Transcripts

ENSMUST00000037484	ENSMUSP00000047220
ENSMUST00000165607	ENSMUSP00000126777
ENSMUST00000164859	ENSMUSP00000128918
ENSMUST00000176640	ENSMUSP00000135494
ENSMUST00000176360	ENSMUSP00000135108
ENSMUST00000177544
ENSMUST00000176648	ENSMUSP00000135219
ENSMUST00000175758
ENSMUST00000175673
ENSMUST00000175910
ENSMUST00000175722
ENSMUST00000176607	ENSMUSP00000135231
ENSMUST00000176563
ENSMUST00000175999	ENSMUSP00000135401
ENSMUST00000176527	ENSMUSP00000135719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0008270	zinc ion binding
GO:0016929	SUMO-specific protease activity

Biological Process

GO:0006508	proteolysis
GO:0016925	protein sumoylation
GO:0016926	protein desumoylation
GO:0070646	protein modification by small protein removal
GO:0090169	regulation of spindle assembly
GO:0090234	regulation of kinetochore assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000112701

View Gene Order

ENSBTAG00000005869

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.412479

RefSeq

NM_146003 XM_006511013 XM_006511014 XM_006511015

OMIM

CCDS

CCDS40705

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas