InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dr1

Summary

InnateDB Gene

IDBG-187799.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dr1

Gene Name

down-regulator of transcription 1

Synonyms

1700121L09Rik; Dr1l; NC2; NC2beta

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029265

Encoded Proteins

IDBP-187801

down-regulator of transcription 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25589657

[Homo sapiens] DR1, a novel host susceptibility gene for influenza A virus replication, suppresses host innate immunity and enhances viral RNA replication.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117505:
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:108268897-108280526

Strand

Forward strand

Band

Transcripts

ENSMUST00000031190	ENSMUSP00000031190
ENSMUST00000154862

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017025	TBP-class protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043966	histone H3 acetylation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117505

View Gene Order

ENSBTAG00000008737

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_226917

HATs acetylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q91WV0

TrEMBL

UniProt Splice Variant

Entrez Gene

13486

UniGene

Mm.303534 Mm.401704

RefSeq

NM_026106

OMIM

CCDS

CCDS19509

HPRD

IMGT

MGI ID

MGI:1100515

MGI Symbol

Dr1

EMBL

AK031057 AK075713 AK090113 AK139866 AK146573 BC013461

GenPept

AAH13461 BAC35903 BAC41099 BAE20474 BAE24166 BAE27269

RNA Seq Atlas

13486