Version 5.4
Mus musculus Gene: Gpsm2
Summary
InnateDB Gene IDBG-187811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpsm2
Gene Name G-protein signalling modulator 2 (AGS3-like, C. elegans)
Synonyms 6230410J09Rik; LGN; Pins
Species Mus musculus
Ensembl Gene ENSMUSG00000027883
Encoded Proteins
IDBP-187813
G-protein signalling modulator 2 (AGS3-like, C. elegans)
IDBP-539421
G-protein signalling modulator 2 (AGS3-like, C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121957:
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:108678638-108722309
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000029482 ENSMUSP00000029482
ENSMUST00000154263
ENSMUST00000145558 ENSMUSP00000115759
ENSMUST00000124043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005515 protein binding
GO:0030695 GTPase regulator activity
GO:0042802 identical protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0050790 regulation of catalytic activity
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000121957
View Gene Order
ENSBTAG00000017124
Not yet available
Cross-References
SwissProt Q8VDU0
TrEMBL A2AEL5 Q3UPG3
UniProt Splice Variant
Entrez Gene 76123
UniGene Mm.226941
RefSeq NM_029522
OMIM
CCDS CCDS51048
HPRD
IMGT
MGI ID MGI:1923373
MGI Symbol Gpsm2
EMBL AK040996 AK143552 AL671917 AY081187 BC021308 CH466607
GenPept AAH21308 AAL87447 BAC30775 BAE25432 EDL01982
RNA Seq Atlas 76123

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca