InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Htr1b

Summary

InnateDB Gene

IDBG-188145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr1b

Gene Name

5-hydroxytryptamine (serotonin) receptor 1B

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049511

Encoded Proteins

IDBP-188147

5-hydroxytryptamine (serotonin) receptor 1B

IDBP-787889

5-hydroxytryptamine (serotonin) receptor 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135312:
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:81628291-81633828

Strand

Reverse strand

Band

Transcripts

ENSMUST00000051005	ENSMUSP00000050898
ENSMUST00000183482	ENSMUSP00000139389

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0008144	drug binding
GO:0051378	serotonin binding

Biological Process

GO:0002031	G-protein coupled receptor internalization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007631	feeding behavior
GO:0014059	regulation of dopamine secretion
GO:0014063	negative regulation of serotonin secretion
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0035690	cellular response to drug
GO:0042220	response to cocaine
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0042756	drinking behavior
GO:0045471	response to ethanol
GO:0046849	bone remodeling
GO:0050795	regulation of behavior
GO:0051385	response to mineralocorticoid
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0071312	cellular response to alkaloid
GO:0071502	cellular response to temperature stimulus