Version 5.4
Mus musculus Gene: Gak
Summary
InnateDB Gene IDBG-188160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gak
Gene Name cyclin G associated kinase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000062234
Encoded Proteins
IDBP-188162
cyclin G associated kinase
IDBP-536801
cyclin G associated kinase
IDBP-532869
cyclin G associated kinase
IDBP-541697
cyclin G associated kinase
IDBP-538206
cyclin G associated kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178950:
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. [provided by RefSeq, Jul 2008]
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the \'cyclin box.\' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:108569411-108629739
Strand Reverse strand
Band F
Transcripts
ENSMUST00000046603 ENSMUSP00000036705
ENSMUST00000156110 ENSMUSP00000115184
ENSMUST00000135225 ENSMUSP00000118008
ENSMUST00000145467 ENSMUSP00000118713
ENSMUST00000133745
ENSMUST00000137872
ENSMUST00000139303 ENSMUSP00000116862
ENSMUST00000145935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0007049 cell cycle
GO:0009913 epidermal cell differentiation
GO:0035622 intrahepatic bile duct development
GO:0048468 cell development
GO:0048853 forebrain morphogenesis
GO:0061436 establishment of skin barrier
GO:0072318 clathrin coat disassembly
GO:0072583 clathrin-mediated endocytosis
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005794 Golgi apparatus
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178950
View Gene Order
ENSBTAG00000019188
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q99KY4
TrEMBL D6RHK5 Q3UDE5
UniProt Splice Variant
Entrez Gene 231580
UniGene Mm.276647 Mm.488147
RefSeq NM_001282051 NM_153569 XM_006534906 XM_006534907 NM_001282052
OMIM
CCDS CCDS19513
HPRD
IMGT
MGI ID MGI:2442153
MGI Symbol Gak
EMBL AC133896 AC161813 AK034637 AK150112 AK166682 BC003958 BC030859 BC060622 BC065052
GenPept AAH03958 AAH30859 AAH60622 AAH65052 BAC28779 BAE29316 BAE38941
RNA Seq Atlas 231580

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca