InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pik3r6

Summary

InnateDB Gene

IDBG-188800.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3r6

Gene Name

phosphoinositide-3-kinase, regulatory subunit 6

Synonyms

BB220380; p84; p84 PIKAP; p87(PIKAP); p87PIKAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046207

Encoded Proteins

IDBP-188802

phosphoinositide-3-kinase, regulatory subunit 6

IDBP-188804

phosphoinositide-3-kinase, regulatory subunit 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:68503019-68552698

Strand

Forward strand

Band

Transcripts

ENSMUST00000102613	ENSMUSP00000099673
ENSMUST00000060441	ENSMUSP00000052522
ENSMUST00000153671
ENSMUST00000126069
ENSMUST00000131669

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity

Biological Process

GO:0001525	angiogenesis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0045766	positive regulation of angiogenesis
GO:0046854	phosphatidylinositol phosphorylation