InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chd4

Summary

InnateDB Gene

IDBG-189058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chd4

Gene Name

chromodomain helicase DNA binding protein 4

Synonyms

9530019N15Rik; AA617397; BC005710; D6Ertd380e; Mi-2beta; mKIAA4075

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063870

Encoded Proteins

IDBP-189060

chromodomain helicase DNA binding protein 4

IDBP-256089

chromodomain helicase DNA binding protein 4

IDBP-256091

chromodomain helicase DNA binding protein 4

IDBP-538354

chromodomain helicase DNA binding protein 4

IDBP-538980

chromodomain helicase DNA binding protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111642:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125095981-125130591

Strand

Forward strand

Band

Transcripts

ENSMUST00000056889	ENSMUSP00000060054
ENSMUST00000112392	ENSMUSP00000108011
ENSMUST00000112390	ENSMUSP00000108009
ENSMUST00000155932
ENSMUST00000155261	ENSMUSP00000122806
ENSMUST00000138968
ENSMUST00000124317	ENSMUSP00000120704
ENSMUST00000132794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008026	ATP-dependent helicase activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification
GO:0043044	ATP-dependent chromatin remodeling
GO:0051225	spindle assembly

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0016581	NuRD complex
GO:0043234	protein complex