Version 5.4
Mus musculus Gene: Cbx5
Summary
InnateDB Gene IDBG-189469.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbx5
Gene Name chromobox 5
Synonyms 2610029O15Rik; C75991; HP1; Hp1a; Hp1alpha
Species Mus musculus
Ensembl Gene ENSMUSG00000009575
Encoded Proteins
IDBP-263741
chromobox homolog 5 (Drosophila HP1a)
IDBP-400675
chromobox homolog 5 (Drosophila HP1a)
IDBP-400676
chromobox homolog 5 (Drosophila HP1a)
IDBP-533502
chromobox homolog 5 (Drosophila HP1a)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000094916:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:103191544-103239816
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000108813 ENSMUSP00000104441
ENSMUST00000118152 ENSMUSP00000113157
ENSMUST00000122182 ENSMUSP00000113158
ENSMUST00000127191 ENSMUSP00000120837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 35 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 113 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0035064 methylated histone binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0070491 repressing transcription factor binding
GO:1990226 histone methyltransferase binding
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000776 kinetochore
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0010369 chromocenter
GO:0016605 PML body
GO:0017053 transcriptional repressor complex
GO:0035097 histone methyltransferase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000094916
View Gene Order
ENSBTAG00000006246
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
e2f_pathway
E2F transcription factor network
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt Q61686
TrEMBL D3Z0U2
UniProt Splice Variant
Entrez Gene 12419
UniGene Mm.262059 Mm.407060 Mm.409229 Mm.415796 Mm.416492 Mm.431478 Mm.451727 Mm.473646
RefSeq NM_001110216 NM_001076789 NM_007626 XM_006520372 XM_006520373 XM_006520374 XM_006520375 XM_006520376
OMIM
CCDS CCDS37231
HPRD
IMGT
MGI ID MGI:109372
MGI Symbol Cbx5
EMBL AC162693 AC164069 AF216290 AK008792 AK018349 AK019198 AK030366 AK030442 AK032975 BC004707 X99641
GenPept AAF80993 AAH04707 BAB25897 BAB31173 BAB31596 BAC26923 BAC26966 BAC28107 CAA67960
RNA Seq Atlas 12419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca