Version 5.4
| Mus musculus Gene: Pgc | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-189475.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Pgc | ||||||
| Gene Name | progastricsin (pepsinogen C) | ||||||
| Synonyms | 2210410L06Rik; Upg-1; Upg1 | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000023987 | ||||||
| Encoded Proteins |
progastricsin (pepsinogen C)
progastricsin (pepsinogen C)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096088:
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 17:47726842-47734482 | ||||||
| Strand | Forward strand | ||||||
| Band | C | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||
| SwissProt | Q9D7R7 | ||||||
| TrEMBL | D3YZ92 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 109820 | ||||||
| UniGene | Mm.22957 | ||||||
| RefSeq | NM_025973 | ||||||
| OMIM | |||||||
| CCDS | CCDS28855 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:98909 | ||||||
| MGI Symbol | Pgc | ||||||
| EMBL | AC124830 AK008886 AK008959 BC099409 | ||||||
| GenPept | AAH99409 BAB25952 BAB25990 | ||||||
| RNA Seq Atlas | 109820 | ||||||