InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnrnpa1

Summary

InnateDB Gene

IDBG-189480.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpa1

Gene Name

heterogeneous nuclear ribonucleoprotein A1

Synonyms

Hdp; HDP-1; hnRNP A1; hnrnp-A1; Hnrpa1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046434

Encoded Proteins

IDBP-176171

heterogeneous nuclear ribonucleoprotein A1

IDBP-189482

heterogeneous nuclear ribonucleoprotein A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135486:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:103240432-103244955

Strand

Forward strand

Band

Transcripts

ENSMUST00000087351	ENSMUSP00000084609
ENSMUST00000036004	ENSMUSP00000042658

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 214 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	214 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0051028	mRNA transport
GO:0051168	nuclear export
GO:0051170	nuclear import

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0019013	viral nucleocapsid
GO:0030529	ribonucleoprotein complex
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome