InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppp1r12a

Summary

InnateDB Gene

IDBG-189483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r12a

Gene Name

protein phosphatase 1, regulatory (inhibitor) subunit 12A

Synonyms

1200015F06Rik; 5730577I22Rik; AA792106; AV099298; D10Ertd625e; Mypt1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019907

Encoded Proteins

IDBP-189485

protein phosphatase 1, regulatory (inhibitor) subunit 12A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058272:
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:108162400-108277575

Strand

Forward strand

Band

Transcripts

ENSMUST00000070663

ENSMUSP00000069257

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0019208	phosphatase regulator activity
GO:0019901	protein kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0030155	regulation of cell adhesion
GO:0035507	regulation of myosin-light-chain-phosphatase activity
GO:0043086	negative regulation of catalytic activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046822	regulation of nucleocytoplasmic transport
GO:0051297	centrosome organization

Cellular Component

GO:0000776	kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0015629	actin cytoskeleton
GO:0043292	contractile fiber
GO:0072357	PTW/PP1 phosphatase complex