Version 5.4
Mus musculus Gene: Ctc1
Summary
InnateDB Gene IDBG-189510.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctc1
Gene Name CTS telomere maintenance complex component 1
Synonyms 1500010J02Rik; AAF-132; AAF132
Species Mus musculus
Ensembl Gene ENSMUSG00000020898
Encoded Proteins
IDBP-189512
RIKEN cDNA 1500010J02 gene
IDBP-274313
RIKEN cDNA 1500010J02 gene
IDBP-537772
RIKEN cDNA 1500010J02 gene
IDBP-542174
RIKEN cDNA 1500010J02 gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178971:
This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69015911-69036473
Strand Forward strand
Band B3
Transcripts
ENSMUST00000021278 ENSMUSP00000021278
ENSMUST00000116359 ENSMUSP00000112063
ENSMUST00000135611
ENSMUST00000161455 ENSMUSP00000124702
ENSMUST00000152979 ENSMUSP00000125028
ENSMUST00000146621
ENSMUST00000161384
ENSMUST00000123871
ENSMUST00000154126
ENSMUST00000143404
ENSMUST00000162256
ENSMUST00000161271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
Biological Process
GO:0000723 telomere maintenance
GO:0006974 cellular response to DNA damage stimulus
GO:0007568 aging
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010833 telomere maintenance via telomere lengthening
GO:0035264 multicellular organism growth
GO:0045740 positive regulation of DNA replication
GO:0048146 positive regulation of fibroblast proliferation
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048539 bone marrow development
GO:0051276 chromosome organization
GO:0071425 hematopoietic stem cell proliferation
GO:0090399 replicative senescence
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0070188 Stn1-Ten1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178971
View Gene Order
ENSBTAG00000007117
Not yet available
Cross-References
SwissProt
TrEMBL E0CXE7
UniProt Splice Variant
Entrez Gene 68964
UniGene Mm.285785
RefSeq NM_001281464 NM_001013256 NM_001143790 NM_001281465
OMIM
CCDS CCDS70214 CCDS36189 CCDS48824
HPRD
IMGT
MGI ID MGI:1916214
MGI Symbol Ctc1
EMBL AL645902
GenPept
RNA Seq Atlas 68964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca