InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nfatc3

Summary

InnateDB Gene

IDBG-189544.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfatc3

Gene Name

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3

Synonyms

C80703; D8Ertd281e; NFAT4; NFATx

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031902

Encoded Proteins

IDBP-262667

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21726630

Nfatc3 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 21726630

[Homo sapiens] NFATC3 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072736:
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:106059603-106130537

Strand

Forward strand

Band

Transcripts

ENSMUST00000109308

ENSMUSP00000104931

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	5 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0045087	innate immune response (InnateDB)
GO:0045333	cellular respiration
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:0055001	muscle cell development
GO:0071277	cellular response to calcium ion
GO:0071285	cellular response to lithium ion