Version 5.4
Mus musculus Gene: Vamp2
Summary
InnateDB Gene IDBG-189759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vamp2
Gene Name vesicle-associated membrane protein 2
Synonyms Syb-2; Syb2; sybII
Species Mus musculus
Ensembl Gene ENSMUSG00000020894
Encoded Proteins
IDBP-189761
vesicle-associated membrane protein 2
IDBP-400320
vesicle-associated membrane protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69088490-69092384
Strand Forward strand
Band B3
Transcripts
ENSMUST00000021273 ENSMUSP00000021273
ENSMUST00000117780 ENSMUSP00000112611
ENSMUST00000149780
ENSMUST00000149559
ENSMUST00000146847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005543 phospholipid binding
GO:0008022 protein C-terminus binding
GO:0017022 myosin binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0006906 vesicle fusion
GO:0009749 response to glucose
GO:0015031 protein transport
GO:0016079 synaptic vesicle exocytosis
GO:0016192 vesicle-mediated transport
GO:0017156 calcium ion-dependent exocytosis
GO:0017157 regulation of exocytosis
GO:0032869 cellular response to insulin stimulus
GO:0043001 Golgi to plasma membrane protein transport
GO:0060291 long-term synaptic potentiation
GO:0060627 regulation of vesicle-mediated transport
GO:0061025 membrane fusion
GO:0090316 positive regulation of intracellular protein transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030136 clathrin-coated vesicle
GO:0030141 secretory granule
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0030672 synaptic vesicle membrane
GO:0031201 SNARE complex
GO:0031410 cytoplasmic vesicle
GO:0042589 zymogen granule membrane
GO:0043005 neuron projection
GO:0043229 intracellular organelle
GO:0043231 intracellular membrane-bounded organelle
GO:0044306 neuron projection terminus
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_217323
Integration of energy metabolism pathway
REACT_209837
Membrane Trafficking pathway
REACT_245631
GABA synthesis, release, reuptake and degradation pathway
REACT_205038
Acetylcholine Neurotransmitter Release Cycle pathway
REACT_188937
Metabolism pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_250087
Neurotransmitter Release Cycle pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_242222
Norepinephrine Neurotransmitter Release Cycle pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_259290
Neuronal System pathway
REACT_229514
Glutamate Neurotransmitter Release Cycle pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
mmu04130
SNARE interactions in vesicular transport pathway
mmu04962
Vasopressin-regulated water reabsorption pathway
mmu04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28643 Mm.418428
RefSeq NM_009497
OMIM
CCDS CCDS24881
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca