Version 5.4
Mus musculus Gene: Nckap1l
Summary
InnateDB Gene IDBG-189791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nckap1l
Gene Name NCK associated protein 1 like
Synonyms 4930568P13Rik; AI463083; Hem1; Hemp1
Species Mus musculus
Ensembl Gene ENSMUSG00000022488
Encoded Proteins
IDBP-189793
NCK associated protein 1 like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19015308
[Homo sapiens] A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity-T development is disrupted in Hem-1 deficient mice
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123338:
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:103453825-103498800
Strand Forward strand
Band F3
Transcripts
ENSMUST00000047405 ENSMUSP00000035400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030295 protein kinase activator activity
GO:0030675 Rac GTPase activator activity
GO:0032403 protein complex binding
Biological Process
GO:0001782 B cell homeostasis
GO:0002262 myeloid cell homeostasis
GO:0006461 protein complex assembly
GO:0006935 chemotaxis
GO:0030011 maintenance of cell polarity
GO:0030593 neutrophil chemotaxis
GO:0030838 positive regulation of actin filament polymerization
GO:0030866 cortical actin cytoskeleton organization
GO:0030890 positive regulation of B cell proliferation
GO:0032700 negative regulation of interleukin-17 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032855 positive regulation of Rac GTPase activity
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0042102 positive regulation of T cell proliferation
GO:0042327 positive regulation of phosphorylation
GO:0042493 response to drug
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0048821 erythrocyte development
GO:0050853 B cell receptor signaling pathway
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0070358 actin polymerization-dependent cell motility
GO:0090023 positive regulation of neutrophil chemotaxis
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0031209 SCAR complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123338
View Gene Order
ENSBTAG00000019686
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30805
RefSeq NM_153505 XM_006520255 XM_006520256
OMIM
CCDS CCDS37236
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca