InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gucy2e

Summary

InnateDB Gene

IDBG-190203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gucy2e

Gene Name

guanylate cyclase 2e

Synonyms

GC-E; GC1; ROS-GC1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020890

Encoded Proteins

IDBP-190205

guanylate cyclase 2e

IDBP-264054

guanylate cyclase 2e

IDBP-264056

guanylate cyclase 2e

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132518:
This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69218117-69237036

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021259	ENSMUSP00000021259
ENSMUST00000108665	ENSMUSP00000104305
ENSMUST00000108664	ENSMUSP00000104304
ENSMUST00000155457

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016849	phosphorus-oxygen lyase activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0007601	visual perception
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction