Version 5.4
Mus musculus Gene: Dazl
Summary
InnateDB Gene IDBG-190403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dazl
Gene Name deleted in azoospermia-like
Synonyms Daz-like; Dazh; Dazl1; Dazla; Tpx-2; Tpx2
Species Mus musculus
Ensembl Gene ENSMUSG00000010592
Encoded Proteins
IDBP-190405
deleted in azoospermia-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:50279394-50293599
Strand Reverse strand
Band C
Transcripts
ENSMUST00000010736 ENSMUSP00000010736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0008494 translation activator activity
GO:0042802 identical protein binding
Biological Process
GO:0001556 oocyte maturation
GO:0007147 female meiosis II
GO:0007275 multicellular organismal development
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0045836 positive regulation of meiosis
GO:0045948 positive regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005844 polysome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000092345
View Gene Order
ENSBTAG00000000502
Not yet available
Cross-References
SwissProt Q64368
TrEMBL Q3TUC3
UniProt Splice Variant
Entrez Gene 13164
UniGene Mm.280641 Mm.476565
RefSeq NM_010021 XM_006523583
OMIM
CCDS CCDS37649
HPRD
IMGT
MGI ID MGI:1342328
MGI Symbol Dazl
EMBL AK014854 AK033183 AK160855 CH466559 U38690 U46694 X95724
GenPept AAB46608 AAC52711 BAB29585 BAC28187 BAE36048 CAA65039 EDL23643
RNA Seq Atlas 13164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca