InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrna7

Summary

InnateDB Gene

IDBG-190675.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna7

Gene Name

cholinergic receptor, nicotinic, alpha polypeptide 7

Synonyms

Acra7; alpha7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030525

Encoded Proteins

IDBP-190677

cholinergic receptor, nicotinic, alpha polypeptide 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175344:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008] The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:63098692-63212526

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032738

ENSMUSP00000032738

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008179	adenylate cyclase binding
GO:0015464	acetylcholine receptor activity
GO:0015643	toxic substance binding
GO:0017081	chloride channel regulator activity
GO:0019901	protein kinase binding
GO:0042166	acetylcholine binding
GO:0042803	protein homodimerization activity
GO:0051117	ATPase binding
GO:0097110	scaffold protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001666	response to hypoxia
GO:0001988	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007271	synaptic transmission, cholinergic
GO:0007613	memory
GO:0008284	positive regulation of cell proliferation
GO:0008306	associative learning
GO:0014061	regulation of norepinephrine secretion
GO:0019228	neuronal action potential
GO:0030317	sperm motility
GO:0032094	response to food
GO:0032225	regulation of synaptic transmission, dopaminergic
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0042391	regulation of membrane potential
GO:0042416	dopamine biosynthetic process
GO:0042698	ovulation cycle
GO:0045471	response to ethanol
GO:0045766	positive regulation of angiogenesis
GO:0048149	behavioral response to ethanol
GO:0050727	regulation of inflammatory response
GO:0050728	negative regulation of inflammatory response
GO:0060112	generation of ovulation cycle rhythm

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009897	external side of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0032279	asymmetric synapse
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane