Version 5.4
Mus musculus Gene: Nfat5
Summary
InnateDB Gene IDBG-190689.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfat5
Gene Name nuclear factor of activated T cells 5
Synonyms AI225870; B130038B15Rik; CAG-8; CAG80; mKIAA0827; NFATL1; nfatz; OREBP; TonEBP
Species Mus musculus
Ensembl Gene ENSMUSG00000003847
Encoded Proteins
IDBP-190691
nuclear factor of activated T-cells 5
IDBP-190693
nuclear factor of activated T-cells 5
IDBP-532026
nuclear factor of activated T-cells 5
IDBP-536637
nuclear factor of activated T-cells 5
IDBP-540206
nuclear factor of activated T-cells 5
IDBP-537784
nuclear factor of activated T-cells 5
IDBP-538069
nuclear factor of activated T-cells 5
IDBP-537444
nuclear factor of activated T-cells 5
IDBP-533012
nuclear factor of activated T-cells 5
IDBP-622270
nuclear factor of activated T-cells 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20685965
Nfat5 is a transcription factor that is upregulated by hypertonicity. Activated Nfat5 enhances LPS-mediated NFkB activity by complexing with NFkB and kB elements in downstream genes.
PMID 22496647
Nfat5 expression is strongly induced by Mycobacterium tuberculosis, and plays an essential role in stimulating HIV replication in co-infected macrophages. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 20685965
[Homo sapiens] NFAT5 is a transcription factor that is upregulated by hypertonicity. Activated NFAT5 enhances LPS-mediated NFkB activity by complexing with NFkB and kB elements in downstream genes. (Demonstrated in murine model)
PMID 22496647
[Homo sapiens] NFAT5 expression is strongly induced by Mycobacterium tuberculosis, and plays an essential role in stimulating HIV replication in co-infected macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102908:
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:107293470-107379517
Strand Forward strand
Band D3
Transcripts
ENSMUST00000075922 ENSMUSP00000075311
ENSMUST00000077440 ENSMUSP00000076653
ENSMUST00000133026 ENSMUSP00000116631
ENSMUST00000151582
ENSMUST00000154474 ENSMUSP00000115036
ENSMUST00000151114 ENSMUSP00000119370
ENSMUST00000149972
ENSMUST00000125721 ENSMUSP00000116094
ENSMUST00000126397
ENSMUST00000148006
ENSMUST00000144100 ENSMUSP00000117554
ENSMUST00000126333 ENSMUSP00000118130
ENSMUST00000147588 ENSMUSP00000122871
ENSMUST00000169453 ENSMUSP00000127784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 1 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001816 cytokine production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070884 regulation of calcineurin-NFAT signaling cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102908
View Gene Order
ENSBTAG00000013412
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.302083 Mm.390057 Mm.406996 Mm.413470
RefSeq NM_001286260 NM_018823 NM_133957 XM_006531191 XM_006531192 XM_006531193 XM_006531194 XM_006531195 XM_006531196 XM_006531197
OMIM
CCDS CCDS22648 CCDS40464 CCDS72168
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca