InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il10

Summary

InnateDB Gene

IDBG-190697.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Il10

Gene Name

interleukin 10

Synonyms

CSIF; Il-10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016529

Encoded Proteins

IDBP-190699

interleukin 10

InnateDB Annotation

Summary

PMID 21849677	Il10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in natural killer (NK) cells. Blockade of Il10 receptor during acute murine cytomegalovirus (CMV) infection markedly reduced the accumulation of cytotoxic NK cells in the spleen and lung.
PMID 22268692	Il10 has opposing functions in anti-microbial responses in its capacity to mediate protective immunity against some organisms but increase susceptibility to other infections.
PMID 22876184	Il10-mediated suppression of natural killer/dendritic cell crosstalk leads to prolonged mouse cytomegalovirus (MCMV) persistence due to poor priming of MCMV-specific T cells.

InnateDB Annotation from Orthologs

Summary

PMID 20154735	[Homo sapiens] IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation.
PMID 20435894	[Homo sapiens] IL10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. It also plays a role in microRNA function, specifically its inhibitory effect on miR-155 expression in response to LPS.
PMID 20883317	[Homo sapiens] IL10 is a pleiotropic cytokine released in many tissues that mediates anti-inflammatory effects. IL10 also has an immunomodulatory role by stimulating NKG2D ligand expression on macrophages, thereby rendering them susceptible to natural killer (NK) cell elimination.
PMID 21849677	[Homo sapiens] IL10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in natural killer (NK) cells. Blockade of Il10 receptor during acute murine cytomegalovirus (CMV) infection markedly reduced the accumulation of cytotoxic NK cells in the spleen and lung. (Demonstrated in murine model)
PMID 22268692	[Homo sapiens] IL10 has opposing functions in anti-microbial responses in its capacity to mediate protective immunity against some organisms but increase susceptibility to other infections.
PMID 22876184	[Homo sapiens] IL10-mediated suppression of natural killer/dendritic cell crosstalk leads to prolonged mouse cytomegalovirus (MCMV) persistence due to poor priming of MCMV-specific T cells. (Demonstrated in mouse)
PMID 23071313	[Homo sapiens] IL10 induces MIR187 to limit the expression of pro-inflammatory cytokines.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136634:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1: 131019845-131024974

Strand

Forward strand

Band

Transcripts

ENSMUST00000016673

ENSMUSP00000016673

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	15	[view]
Protein‑Protein	1	[view]
Protein‑DNA	13	[view]
Protein‑RNA	0
DNA-DNA	1	[view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Accession

GO Term

Molecular Function

GO:0005125	cytokine activity
GO:0005141	interleukin-10 receptor binding

Biological Process

GO:0001818	negative regulation of cytokine production
GO:0002237	response to molecule of bacterial origin
GO:0002740	negative regulation of cytokine secretion involved in immune response
GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus
GO:0002904	positive regulation of B cell apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0010033	response to organic substance
GO:0010468	regulation of gene expression
GO:0014823	response to activity
GO:0014854	response to inactivity
GO:0030886	negative regulation of myeloid dendritic cell activation
GO:0030889	negative regulation of B cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0032689	negative regulation of interferon-gamma production
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032800	receptor biosynthetic process
GO:0032868	response to insulin stimulus
GO:0034465	response to carbon monoxide
GO:0042493	response to drug
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0043066	negative regulation of apoptotic process
GO:0044130	negative regulation of growth of symbiont in host
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050715	positive regulation of cytokine secretion
GO:0050728	negative regulation of inflammatory response
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384	response to glucocorticoid stimulus
GO:0051930	regulation of sensory perception of pain
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005615

extracellular space

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID	Gene Order	Method	Confidence	Comments
ENSG00000136634		Ortholuge	SSD Ortholog	Ortholog supports species divergence
ENSBTAG00000006685	Not yet available	Ortholuge	SSD Ortholog	Ortholog supports species divergence

Pathways

NETPATH

REACTOME

KEGG

mmu05143

African trypanosomiasis

mmu05330

Allograft rejection

mmu05146

Amoebiasis

mmu05310

Asthma

mmu05320

Autoimmune thyroid disease

mmu05142

Chagas disease (American trypanosomiasis)

mmu04060

Cytokine-cytokine receptor interaction

mmu04672

Intestinal immune network for IgA production

mmu04630

Jak-STAT signaling pathway

mmu05140

Leishmaniasis

mmu05144

Malaria

mmu05150

Staphylococcus aureus infection

mmu05322

Systemic lupus erythematosus

mmu04660

T cell receptor signaling pathway

mmu05145

Toxoplasmosis

INOH