Mus musculus Gene: Il10
Summary
InnateDB Gene IDBG-190697.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Il10
Gene Name interleukin 10
Synonyms CSIF; Il-10;
Species Mus musculus
Ensembl Gene ENSMUSG00000016529
Encoded Proteins
interleukin 10
Protein Structure
InnateDB Annotation
Summary
Il10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in natural killer (NK) cells. Blockade of Il10 receptor during acute murine cytomegalovirus (CMV) infection markedly reduced the accumulation of cytotoxic NK cells in the spleen and lung.
Il10 has opposing functions in anti-microbial responses in its capacity to mediate protective immunity against some organisms but increase susceptibility to other infections.
Il10-mediated suppression of natural killer/dendritic cell crosstalk leads to prolonged mouse cytomegalovirus (MCMV) persistence due to poor priming of MCMV-specific T cells.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation.
[Homo sapiens] IL10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. It also plays a role in microRNA function, specifically its inhibitory effect on miR-155 expression in response to LPS.
[Homo sapiens] IL10 is a pleiotropic cytokine released in many tissues that mediates anti-inflammatory effects. IL10 also has an immunomodulatory role by stimulating NKG2D ligand expression on macrophages, thereby rendering them susceptible to natural killer (NK) cell elimination.
[Homo sapiens] IL10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in natural killer (NK) cells. Blockade of Il10 receptor during acute murine cytomegalovirus (CMV) infection markedly reduced the accumulation of cytotoxic NK cells in the spleen and lung. (Demonstrated in murine model)
[Homo sapiens] IL10 has opposing functions in anti-microbial responses in its capacity to mediate protective immunity against some organisms but increase susceptibility to other infections.
[Homo sapiens] IL10-mediated suppression of natural killer/dendritic cell crosstalk leads to prolonged mouse cytomegalovirus (MCMV) persistence due to poor priming of MCMV-specific T cells. (Demonstrated in mouse)
[Homo sapiens] IL10 induces MIR187 to limit the expression of pro-inflammatory cytokines.
[Homo sapiens] MIR145 directly targets HDAC11 to promote IL10 expression in TLR4-triggered macrophages.
[Homo sapiens] HIV-1 infection of macrophages modulates host responses to co-infection with Mycobacterium tuberculosis by attenuating IL10 responses thus contributing to the pathogenesis of tuberculosis in HIV-1??infected patients.
[Homo sapiens] Secreted CCNA2 (CCN1) promotes anti-inflammatory cytokine IL10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppresses TNF, CXCL2 and neutrophil infiltration in the lungs.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136634:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:131019845-131024974
Strand Forward strand
Band E4
Transcripts
ENSMUST00000016673 ENSMUSP00000016673
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 1 [view]
Protein-DNA 14 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005141 interleukin-10 receptor binding
Biological Process
GO:0001818 negative regulation of cytokine production
GO:0002237 response to molecule of bacterial origin
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus
GO:0002904 positive regulation of B cell apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0014823 response to activity
GO:0014854 response to inactivity
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0030889 negative regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032800 receptor biosynthetic process
GO:0032868 response to insulin stimulus
GO:0034465 response to carbon monoxide
GO:0042493 response to drug
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0044130 negative regulation of growth of symbiont in host
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050715 positive regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid stimulus
GO:0051930 regulation of sensory perception of pain
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
T cell receptor signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Intestinal immune network for IgA production pathway
Staphylococcus aureus infection pathway
Leishmaniasis pathway
Amoebiasis pathway
Malaria pathway
Asthma pathway
Allograft rejection pathway
Systemic lupus erythematosus pathway
Autoimmune thyroid disease pathway
Toxoplasmosis pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
INOH
JAK STAT pathway and regulation pathway
IL-10 signaling pathway
GPCR signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Asthma pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Amoebiasis pathway
Malaria pathway
Chagas disease (American trypanosomiasis) pathway
Intestinal immune network for IgA production pathway
African trypanosomiasis pathway
Toxoplasmosis pathway
Cytokine-cytokine receptor interaction pathway
T cell receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
IL-10 signaling pathway
GPCR signaling pathway
PID BIOCARTA
Il-10 anti-inflammatory signaling pathway [Biocarta view]
PID NCI
AP-1 transcription factor network
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt P18893
TrEMBL
UniProt Splice Variant
Entrez Gene 16153
UniGene Mm.874
RefSeq NM_010548
OMIM
CCDS CCDS15265
HPRD
IMGT
MGI ID 96537 MGI:96537
MGI Symbol Il10
EMBL AL513351 BC120612 BC137844 CH466520 M37897 M84340
GenPept AAA39274 AAA39275 AAI20613 AAI37845 CAM14013 EDL39722
ImmGen Il10 (murine)
RNA Seq Atlas 16153