Version 5.4
Mus musculus Gene: Wrap53
Summary
InnateDB Gene IDBG-190972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wrap53
Gene Name WD repeat containing, antisense to TP53
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041346
Encoded Proteins
IDBP-190974
WD repeat containing, antisense to TP53
IDBP-534345
WD repeat containing, antisense to TP53
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141499:
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69561758-69580255
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000048139 ENSMUSP00000047825
ENSMUST00000155894
ENSMUST00000132548 ENSMUSP00000121040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0032203 telomere formation via telomerase
GO:0051973 positive regulation of telomerase activity
Cellular Component
GO:0005634 nucleus
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141499
View Gene Order
ENSBTAG00000001071
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7974
Telomere Extension By Telomerase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_8030
Extension of Telomeres pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I7HJ86
UniProt Splice Variant
Entrez Gene 216853
UniGene Mm.31586 Mm.404762
RefSeq NM_144824
OMIM
CCDS CCDS24897
HPRD
IMGT
MGI ID MGI:2384933
MGI Symbol Wrap53
EMBL AL731687
GenPept CAI52014
RNA Seq Atlas 216853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca