InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fkbp4

Summary

InnateDB Gene

IDBG-191195.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fkbp4

Gene Name

FK506 binding protein 4

Synonyms

59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP52; FKPB52; p59

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030357

Encoded Proteins

IDBP-191197

FK506 binding protein 4

IDBP-531897

FK506 binding protein 4

IDBP-537877

FK506 binding protein 4

IDBP-536010

FK506 binding protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004478:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:128429735-128438677

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032508	ENSMUSP00000032508
ENSMUST00000139448	ENSMUSP00000114939
ENSMUST00000150387	ENSMUSP00000119930
ENSMUST00000151796	ENSMUSP00000122087

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0005528	FK506 binding
GO:0031072	heat shock protein binding
GO:0032767	copper-dependent protein binding
GO:0035259	glucocorticoid receptor binding
GO:0044822	poly(A) RNA binding
GO:0048156	tau protein binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0006463	steroid hormone receptor complex assembly
GO:0006825	copper ion transport
GO:0007566	embryo implantation
GO:0010977	negative regulation of neuron projection development
GO:0018208	peptidyl-proline modification
GO:0030521	androgen receptor signaling pathway
GO:0030850	prostate gland development
GO:0031111	negative regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0031503	protein complex localization
GO:0046661	male sex differentiation
GO:0048608	reproductive structure development
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0044295	axonal growth cone
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome