InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plod2

Summary

InnateDB Gene

IDBG-191238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plod2

Gene Name

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

Synonyms

D530025C14Rik; LH2; Plod-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032374

Encoded Proteins

IDBP-191240

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

IDBP-542321

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152952:
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:92542223-92608428

Strand

Forward strand

Band

E3.3

Transcripts

ENSMUST00000070522	ENSMUSP00000068611
ENSMUST00000160359	ENSMUSP00000125373
ENSMUST00000160142
ENSMUST00000161906
ENSMUST00000190075

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008475	procollagen-lysine 5-dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0001666	response to hypoxia
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0030867	rough endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000152952

View Gene Order

ENSBTAG00000007331

Not yet available

Pathways

NETPATH

REACTOME

REACT_199045

Collagen formation pathway

REACT_198984

Collagen biosynthesis and modifying enzymes pathway

REACT_206066

Extracellular matrix organization pathway

KEGG

mmu00310

Lysine degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121139

Collagen biosynthesis and modifying enzymes pathway

REACT_118779

Extracellular matrix organization pathway

REACT_120729

Collagen formation pathway

KEGG

hsa00310

Lysine degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.402612 Mm.79983

RefSeq

NM_001142916 NM_011961

OMIM

CCDS

CCDS23408 CCDS52887

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas