InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcd3

Summary

InnateDB Gene

IDBG-191244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcd3

Gene Name

ATP-binding cassette, sub-family D (ALD), member 3

Synonyms

AI313901; AU018866; AW146054; PMP68; PMP70; Pxmp1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028127

Encoded Proteins

IDBP-191246

ATP-binding cassette, sub-family D (ALD), member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:121758909-121815302

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029770	ENSMUSP00000029770
ENSMUST00000162299
ENSMUST00000162262
ENSMUST00000161742

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006810	transport
GO:0007031	peroxisome organization
GO:0042760	very long-chain fatty acid catabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117528

View Gene Order

ENSBTAG00000009698

Not yet available

Pathways

NETPATH

REACTOME

REACT_197984

ABCA transporters in lipid homeostasis pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_237882

ABC-family proteins mediated transport pathway

KEGG

mmu02010

ABC transporters pathway

mmu04146

Peroxisome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_111158

ABCA transporters in lipid homeostasis pathway

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.399042 Mm.474013 Mm.487771

RefSeq

NM_008991 XM_006501152

OMIM

CCDS

CCDS17806

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas