Mus musculus Gene: Ebi3

Summary
InnateDB Gene IDBG-191286.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Ebi3
Gene Name Epstein-Barr virus induced gene 3
Synonyms EBI-3; IL-27
Species Mus musculus
Ensembl Gene ENSMUSG00000003206
Encoded Proteins
IDBP-191288 Epstein-Barr virus induced gene 3
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105246:
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 55952623-55957021
Strand Forward strand
Band D
Transcripts
ENSMUST00000003274  ENSMUSP00000003274
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein‑Protein  2
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004896 cytokine receptor activity
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045523 interleukin-27 receptor binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000105246 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000012829 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
il27pathway IL27-mediated signaling events
Cross-References
SwissProt O35228 
TrEMBL Q3U1K3
UniProt Splice Variant
Entrez Gene 50498 
UniGene Mm.256798
RefSeq NM_015766 
OMIM
CCDS CCDS28888 
HPRD
IMGT
MGI ID MGI:1354171 
MGI Symbol Ebi3
EMBL AF013114 AK155023 AK155903 BC008209 CH466559
GenPept AAB67115  AAH08209  BAE32996  BAE33494  EDL23693 
ImmGen Ebi3 (murine) 
RNA Seq Atlas 50498