Version 5.4
Mus musculus Gene: Ebi3
Summary
InnateDB Gene IDBG-191286.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ebi3
Gene Name Epstein-Barr virus induced gene 3
Synonyms EBI-3; IL-27
Species Mus musculus
Ensembl Gene ENSMUSG00000003206
Encoded Proteins
IDBP-191288
Epstein-Barr virus induced gene 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105246:
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:55952623-55957021
Strand Forward strand
Band D
Transcripts
ENSMUST00000003274 ENSMUSP00000003274
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045523 interleukin-27 receptor binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105246
View Gene Order
ENSBTAG00000012829
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
il27pathway
IL27-mediated signaling events
Cross-References
SwissProt O35228
TrEMBL Q3U1K3
UniProt Splice Variant
Entrez Gene 50498
UniGene Mm.256798
RefSeq NM_015766
OMIM
CCDS CCDS28888
HPRD
IMGT
MGI ID MGI:1354171
MGI Symbol Ebi3
EMBL AF013114 AK155023 AK155903 BC008209 CH466559
GenPept AAB67115 AAH08209 BAE32996 BAE33494 EDL23693
RNA Seq Atlas 50498

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca