InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tjp1

Summary

InnateDB Gene

IDBG-191302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tjp1

Gene Name

tight junction protein 1

Synonyms

ZO1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030516

Encoded Proteins

IDBP-191304

tight junction protein 1

IDBP-191306

tight junction protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104067:
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:65296165-65371239

Strand

Reverse strand

Band

Transcripts

ENSMUST00000102592	ENSMUSP00000099652
ENSMUST00000032729	ENSMUSP00000032729
ENSMUST00000132036
ENSMUST00000144961

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding

Biological Process

GO:0001825	blastocyst formation
GO:0007605	sensory perception of sound
GO:0032496	response to lipopolysaccharide
GO:0042493	response to drug
GO:0043116	negative regulation of vascular permeability
GO:0045471	response to ethanol
GO:0071000	response to magnetism
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005921	gap junction
GO:0005923	tight junction
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030054	cell junction
GO:0031674	I band
GO:0043296	apical junction complex
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus