Version 5.4
Mus musculus Gene: Ist1
Summary
InnateDB Gene IDBG-191367.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ist1
Gene Name increased sodium tolerance 1 homolog (yeast)
Synonyms 2400003C14Rik; AW536298; mKIAA0174
Species Mus musculus
Ensembl Gene ENSMUSG00000031729
Encoded Proteins
IDBP-191369
RIKEN cDNA 2400003C14 gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182149:
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:109671322-109693294
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000034164 ENSMUSP00000034164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0090541 MIT domain binding
Biological Process
GO:0000910 cytokinesis
GO:0008104 protein localization
GO:0009838 abscission
GO:0019076 viral release from host cell
GO:0045184 establishment of protein localization
GO:0045862 positive regulation of proteolysis
GO:0046745 viral capsid secondary envelopment
GO:0048672 positive regulation of collateral sprouting
GO:0051301 cell division
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030496 midbody
GO:0070062 extracellular vesicular exosome
GO:0090543 Flemming body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000182149
View Gene Order
ENSBTAG00000019883
Not yet available
Cross-References
SwissProt Q9CX00
TrEMBL
UniProt Splice Variant
Entrez Gene 71955
UniGene Mm.470640
RefSeq NM_028018
OMIM
CCDS CCDS22655
HPRD
IMGT
MGI ID MGI:1919205
MGI Symbol Ist1
EMBL AK010262 AK088192 AK122215 AK152830 BC017605
GenPept AAH17605 BAB26804 BAC40200 BAC65497 BAE31530
RNA Seq Atlas 71955

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca