InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ap1g1

Summary

InnateDB Gene

IDBG-191480.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap1g1

Gene Name

adaptor protein complex AP-1, gamma 1 subunit

Synonyms

AA409002; Adtg; AU041323; AW551707; D8Ertd374e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031731

Encoded Proteins

IDBP-191482

adaptor protein complex AP-1, gamma 1 subunit

IDBP-191484

adaptor protein complex AP-1, gamma 1 subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166747:
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:109778554-109864204

Strand

Forward strand

Band

Transcripts

ENSMUST00000093157	ENSMUSP00000090844
ENSMUST00000034171	ENSMUSP00000034171
ENSMUST00000173200
ENSMUST00000172892
ENSMUST00000173476

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0017137	Rab GTPase binding
GO:0019894	kinesin binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0035646	endosome to melanosome transport
GO:0043323	positive regulation of natural killer cell degranulation
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0090160	Golgi to lysosome transport

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle
GO:0030665	clathrin-coated vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome