InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abca4

Summary

InnateDB Gene

IDBG-191485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abca4

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 4

Synonyms

Abc10; Abcr; AW050280; D430003I15Rik; RmP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028125

Encoded Proteins

IDBP-191487

ATP-binding cassette, sub-family A (ABC1), member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein was the first of the ABC transporters to be observed in photoreceptors and may play a role in the photoresponse. Mutations in the human gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:122044443-122180061

Strand

Forward strand

Band

Transcripts

ENSMUST00000013995	ENSMUSP00000013995
ENSMUST00000132199
ENSMUST00000150738
ENSMUST00000126552
ENSMUST00000140913
ENSMUST00000136624
ENSMUST00000139239
ENSMUST00000141135
ENSMUST00000144949
ENSMUST00000137616
ENSMUST00000136358

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006649	phospholipid transfer to membrane
GO:0006810	transport
GO:0007601	visual perception
GO:0045332	phospholipid translocation
GO:0045494	photoreceptor cell maintenance
GO:0050896	response to stimulus
GO:0055085	transmembrane transport