InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gclm

Summary

InnateDB Gene

IDBG-191550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gclm

Gene Name

glutamate-cysteine ligase, modifier subunit

Synonyms

AI649393; Gcmc; Glclr

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028124

Encoded Proteins

IDBP-191552

glutamate-cysteine ligase, modifier subunit

IDBP-539180

glutamate-cysteine ligase, modifier subunit

IDBP-717122

IDBP-717011

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023909:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:122245557-122269984

Strand

Forward strand

Band

Transcripts

ENSMUST00000029769	ENSMUSP00000029769
ENSMUST00000137540
ENSMUST00000149983	ENSMUSP00000123683
ENSMUST00000178826	ENSMUSP00000136987
ENSMUST00000176445	ENSMUSP00000134906
ENSMUST00000176761

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004357	glutamate-cysteine ligase activity
GO:0035226	glutamate-cysteine ligase catalytic subunit binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006534	cysteine metabolic process
GO:0006536	glutamate metabolic process
GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0035229	positive regulation of glutamate-cysteine ligase activity
GO:0042493	response to drug
GO:0043524	negative regulation of neuron apoptotic process
GO:0050880	regulation of blood vessel size
GO:0051409	response to nitrosative stress
GO:0051900	regulation of mitochondrial depolarization
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway