Version 5.4
Mus musculus Gene: Frs2
Summary
InnateDB Gene IDBG-191602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Frs2
Gene Name fibroblast growth factor receptor substrate 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020170
Encoded Proteins
IDBP-191604
fibroblast growth factor receptor substrate 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166225:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:117070129-117148474
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000020381 ENSMUSP00000020381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005515 protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001702 gastrulation with mouth forming second
GO:0001759 organ induction
GO:0002088 lens development in camera-type eye
GO:0003281 ventricular septum development
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007405 neuroblast proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008595 anterior/posterior axis specification, embryo
GO:0030900 forebrain development
GO:0042981 regulation of apoptotic process
GO:0046619 optic placode formation involved in camera-type eye formation
GO:0050678 regulation of epithelial cell proliferation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0070307 lens fiber cell development
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166225
View Gene Order
ENSBTAG00000019155
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_198525
Negative regulation of FGFR signaling pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_262560
Frs2-mediated activation pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_240139
PI3K Cascade pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_231290
Signalling to ERKs pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_196455
Signaling by FGFR mutants pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_234357
FRS2-mediated cascade pathway
REACT_206286
GAB1 signalosome pathway
REACT_243154
IRS-related events pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242206
IRS-mediated signalling pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04722
Neurotrophin signaling pathway pathway
INOH
INOH website
FGF8 signaling (Mouse) pathway
INOH website
FGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_21270
PI-3K cascade pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
INOH website
FGF signaling pathway pathway
PID NCI
fgf_pathway
FGF signaling pathway
ret_pathway
Signaling events regulated by Ret tyrosine kinase
shp2_pathway
SHP2 signaling
Cross-References
SwissProt Q8C180
TrEMBL
UniProt Splice Variant
Entrez Gene 327826
UniGene Mm.135965
RefSeq NM_177798 XM_006513790
OMIM
CCDS CCDS24190
HPRD
IMGT
MGI ID MGI:1100860
MGI Symbol Frs2
EMBL AK028813 BC043109 BC055334
GenPept AAH43109 AAH55334 BAC26132
RNA Seq Atlas 327826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca