InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atr

Summary

InnateDB Gene

IDBG-191646.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atr

Gene Name

ataxia telangiectasia and Rad3 related

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032409

Encoded Proteins

IDBP-191648

ataxia telangiectasia and Rad3 related

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175054:
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:95857597-95951644

Strand

Forward strand

Band

E3.3

Transcripts

ENSMUST00000034980	ENSMUSP00000034980
ENSMUST00000187356
ENSMUST00000185473
ENSMUST00000189602
ENSMUST00000186061
ENSMUST00000191269
ENSMUST00000186127
ENSMUST00000188164
ENSMUST00000190644
ENSMUST00000186997
ENSMUST00000188088
ENSMUST00000186524

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0008156	negative regulation of DNA replication
GO:0018105	peptidyl-serine phosphorylation
GO:0034644	cellular response to UV
GO:0042493	response to drug
GO:0043393	regulation of protein binding
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	protein autophosphorylation
GO:0071480	cellular response to gamma radiation
GO:0090399	replicative senescence