InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Klrk1

Summary

InnateDB Gene

IDBG-192142.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klrk1

Gene Name

killer cell lectin-like receptor subfamily K, member 1

Synonyms

D6H12S2489E; NKG2-D; Nkg2d

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030149

Encoded Proteins

IDBP-192144

killer cell lectin-like receptor subfamily K, member 1

IDBP-192148

killer cell lectin-like receptor subfamily K, member 1

IDBP-627474

killer cell lectin-like receptor subfamily K, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213809:
This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010] Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:129610323-129623864

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032252	ENSMUSP00000032252
ENSMUST00000095412	ENSMUSP00000093061
ENSMUST00000152256
ENSMUST00000137660
ENSMUST00000168919	ENSMUSP00000130398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0030246	carbohydrate binding
GO:0032394	MHC class Ib receptor activity
GO:0042288	MHC class I protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002223	stimulatory C-type lectin receptor signaling pathway
GO:0030101	natural killer cell activation
GO:0030154	cell differentiation
GO:0032729	positive regulation of interferon-gamma production
GO:0045087	innate immune response
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050830	defense response to Gram-positive bacterium
GO:0071222	cellular response to lipopolysaccharide