Version 5.4
Mus musculus Gene: Ifng
Summary
InnateDB Gene IDBG-192196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ifng
Gene Name interferon gamma
Synonyms Ifg; IFN-g
Species Mus musculus
Ensembl Gene ENSMUSG00000055170
Encoded Proteins
IDBP-192198
interferon gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23754402
IFNG is produced by neutrophils to mount host protection against intracellular pathogens.
PMID 23818011
IFNG produced by natural killer cells exacerbates Listeria monocytogenes infection by inhibiting granulocyte recruitment.
PMID 26065469
Ticam2 mediates antibacterial defence during Gram-negative pneumonia by inducing Ifng at the primary site of infection.
PMID 26092469
Group 2 innate lymphoid cell (ILC2)-intrinsic Il33 signalling and Icosl expression promote regulatory T cell accumulation, whereas the inflammatory cytokine Ifng counter-regulated the effects of Il33, in part through direct effects on ILC2s.
PMID 26843324
Irf8-Ifng circuit is a novel gastric innate immune mechanism in the host defense against infection with Helicobacter pylori.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:118441047-118445892
Strand Forward strand
Band D2
Transcripts
ENSMUST00000068592 ENSMUSP00000063800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 3 [view]
Protein-DNA 20 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 3 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005133 interferon-gamma receptor binding
GO:0005515 protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001781 neutrophil apoptotic process
GO:0002026 regulation of the force of heart contraction
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002250 adaptive immune response
GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0019882 antigen processing and presentation
GO:0030593 neutrophil chemotaxis
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031642 negative regulation of myelination
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0032700 negative regulation of interleukin-17 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0042102 positive regulation of T cell proliferation
GO:0042493 response to drug
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0044130 negative regulation of growth of symbiont in host
GO:0044146 negative regulation of growth of symbiont involved in interaction with host
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045666 positive regulation of neuron differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050776 regulation of immune response
GO:0050796 regulation of insulin secretion
GO:0050954 sensory perception of mechanical stimulus
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of other organism
GO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0071222 cellular response to lipopolysaccharide
GO:0071351 cellular response to interleukin-18
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0098908 regulation of neuronal action potential
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000345 regulation of hepatocyte proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198645
Regulation of IFNG signaling pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu03050
Proteasome pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04940
Type I diabetes mellitus pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04140
Regulation of autophagy pathway
mmu04612
Antigen processing and presentation pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu05330
Allograft rejection pathway
mmu05332
Graft-versus-host disease pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05140
Leishmaniasis pathway
mmu05146
Amoebiasis pathway
mmu04380
Osteoclast differentiation pathway
mmu05144
Malaria pathway
mmu05145
Toxoplasmosis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05143
African trypanosomiasis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
INOH website
IFN gamma signaling pathway
PID NCI
Cross-References
SwissProt P01580
TrEMBL Q6TDH0
UniProt Splice Variant
Entrez Gene 15978
UniGene
RefSeq NM_008337
OMIM
CCDS CCDS24200
HPRD
IMGT
MGI ID MGI:107656
MGI Symbol Ifng
EMBL AK089574 AY423847 BC119063 BC119065 K00083
GenPept AAA37894 AAI19064 AAI19066 AAR00339 BAC40926
RNA Seq Atlas 15978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca