InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Irak3

Summary

InnateDB Gene

IDBG-192499.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irak3

Gene Name

interleukin-1 receptor-associated kinase 3

Synonyms

4833428C18Rik; AI563835; IRAK-M

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020227

Encoded Proteins

IDBP-192501

interleukin-1 receptor-associated kinase 3

IDBP-532440

interleukin-1 receptor-associated kinase 3

IDBP-541209

interleukin-1 receptor-associated kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22154382

Irak3 dampens the innate immune response in airway epithelial cells by inhibiting Tlr2 signalling in an Il13-dependent manner. (Demonstrated in human)

PMID 22492852

Irak3 impairs host defence during pneumococcal pneumonia at the primary site of infection.

InnateDB Annotation from Orthologs

Summary

PMID 17982103

[Homo sapiens] IRAK3 upregulation by lipopolysaccharide (LPS) is largely dependent on TNF-alpha and LPS tolerance in human endotoxemia models is associated with IRAK3 up-regulation.

PMID 17379480

[Homo sapiens] IRAK3 selectively attenuates Pam3CSK4-induced MAPK14 (p38) activation through an IRAK1 independent and MKP1 dependent pathway.

PMID 12620219

[Homo sapiens] IRAK3 is part of the interleukin-1 receptor-associated kinase (IRAK) family of proteins that mediate activation of nuclear factor-kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways.

PMID 19809574

[Homo sapiens] IRAK3 is one of the negative regulators that contribute to the attenuation of NF-kappaB activation and it negatively regulates the alternative NF-kappaB pathway in a ligand-specific manner.

PMID 14660668

[Homo sapiens] IRAK3 induction and inhibition of kinase activity of IRAK1 are crucial to peptidoglycan-induced tolerance in macrophages.

PMID 12150927

[Homo sapiens] IRAK3 regulates Toll-like receptor (TLR) signalling and innate immune homeostasis where IRAK3 is induced upon TLR stimulation and negatively regulates TLR signalling.

PMID 20042589

[Homo sapiens] IRAK3 is critical to preventing deleterious neutrophil-dependent lung injury during influenza infection of the respiratory tract.

PMID 21098228

[Homo sapiens] IRAK3 is strongly expressed in resting alveolar macrophages and blunts TNF expression to protect the host from the injurious effect of bacterial-induced inflammation. The inhibitory function of IRAK3 is abolished when it is cleaved by CASP6, which allows the induction of the NFKB pathway and the expression of TNF.

PMID 22154382

[Homo sapiens] IRAK3 dampens the innate immune response in airway epithelial cells by inhibiting TLR2 signalling in an IL13-dependent manner.

PMID 22492852

[Homo sapiens] IRAK3 impairs host defence during pneumococcal pneumonia at the primary site of infection. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090376:
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:120141648-120202130

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020448	ENSMUSP00000020448
ENSMUST00000145665	ENSMUSP00000118038
ENSMUST00000135106	ENSMUSP00000123604
ENSMUST00000140237
ENSMUST00000143100

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0009615	response to virus
GO:0010933	positive regulation of macrophage tolerance induction
GO:0010936	negative regulation of macrophage cytokine production
GO:0019221	cytokine-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042177	negative regulation of protein catabolic process
GO:0042981	regulation of apoptotic process
GO:0043242	negative regulation of protein complex disassembly
GO:0043244	regulation of protein complex disassembly
GO:0043330	response to exogenous dsRNA
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045824	negative regulation of innate immune response
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070555	response to interleukin-1