Version 5.4
Mus musculus Gene: Nr2f2
Summary
InnateDB Gene IDBG-192528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr2f2
Gene Name nuclear receptor subfamily 2, group F, member 2
Synonyms 2700033K02Rik; 9430015G03Rik; Aporp1; ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40; Tcfcoup2
Species Mus musculus
Ensembl Gene ENSMUSG00000030551
Encoded Proteins
IDBP-192530
nuclear receptor subfamily 2, group F, member 2
IDBP-192532
nuclear receptor subfamily 2, group F, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185551:
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:70351946-70366735
Strand Reverse strand
Band C
Transcripts
ENSMUST00000032768 ENSMUSP00000032768
ENSMUST00000089565 ENSMUSP00000086993
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001893 maternal placenta development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001945 lymph vessel development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007519 skeletal muscle tissue development
GO:0009566 fertilization
GO:0009952 anterior/posterior pattern specification
GO:0009956 radial pattern formation
GO:0010596 negative regulation of endothelial cell migration
GO:0030522 intracellular receptor signaling pathway
GO:0030900 forebrain development
GO:0032355 response to estradiol
GO:0043401 steroid hormone mediated signaling pathway
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048514 blood vessel morphogenesis
GO:0060173 limb development
GO:0060674 placenta blood vessel development
GO:0060707 trophoblast giant cell differentiation
GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185551
View Gene Order
ENSBTAG00000018007
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
hnf3apathway
FOXA1 transcription factor network
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt P43135
TrEMBL Q3UST6
UniProt Splice Variant
Entrez Gene 11819
UniGene Mm.158143 Mm.432210 Mm.472219
RefSeq NM_009697 XM_006540578 NM_183261
OMIM
CCDS CCDS21359 CCDS21358
HPRD
IMGT
MGI ID MGI:1352452
MGI Symbol Nr2f2
EMBL AK140125 BC042484 U07635 X76653
GenPept AAA19854 AAH42484 BAE24245 CAA54096
RNA Seq Atlas 11819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca