Version 5.4
Mus musculus Gene: Camk2d
Summary
InnateDB Gene IDBG-192589.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Camk2d
Gene Name calcium/calmodulin-dependent protein kinase II, delta
Synonyms [d]-CaMKII; 2810011D23Rik; 8030469K03Rik; CaMK II
Species Mus musculus
Ensembl Gene ENSMUSG00000053819
Encoded Proteins
IDBP-192591
calcium/calmodulin-dependent protein kinase II, delta
IDBP-192593
calcium/calmodulin-dependent protein kinase II, delta
IDBP-268834
calcium/calmodulin-dependent protein kinase II, delta
IDBP-268836
calcium/calmodulin-dependent protein kinase II, delta
IDBP-268838
calcium/calmodulin-dependent protein kinase II, delta
IDBP-268840
calcium/calmodulin-dependent protein kinase II, delta
IDBP-535644
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620627
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620628
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620624
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620626
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620629
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620631
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620632
calcium/calmodulin-dependent protein kinase II, delta
IDBP-620633
calcium/calmodulin-dependent protein kinase II, delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145349:
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:126596302-126844913
Strand Forward strand
Band G1
Transcripts
ENSMUST00000066466 ENSMUSP00000063359
ENSMUST00000066452 ENSMUSP00000066996
ENSMUST00000106402 ENSMUSP00000102010
ENSMUST00000106401 ENSMUSP00000102009
ENSMUST00000106400 ENSMUSP00000102008
ENSMUST00000106399 ENSMUSP00000102007
ENSMUST00000143383
ENSMUST00000149311
ENSMUST00000134466 ENSMUSP00000114801
ENSMUST00000145454 ENSMUSP00000130769
ENSMUST00000131869 ENSMUSP00000126412
ENSMUST00000131156
ENSMUST00000129293
ENSMUST00000134987
ENSMUST00000147043
ENSMUST00000163226 ENSMUSP00000133019
ENSMUST00000169051 ENSMUSP00000132554
ENSMUST00000171289 ENSMUSP00000129999
ENSMUST00000171950
ENSMUST00000167985 ENSMUSP00000126207
ENSMUST00000167417 ENSMUSP00000131124
ENSMUST00000170149 ENSMUSP00000130305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031432 titin binding
GO:0044325 ion channel binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0002028 regulation of sodium ion transport
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0046777 protein autophosphorylation
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0060341 regulation of cellular localization
GO:0086003 cardiac muscle cell contraction
GO:1901897 regulation of relaxation of cardiac muscle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0014704 intercalated disc
GO:0030315 T-tubule
GO:0031594 neuromuscular junction
GO:0033017 sarcoplasmic reticulum membrane
GO:0034704 calcium channel complex
GO:0043025 neuronal cell body
GO:0043194 axon initial segment
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145349
View Gene Order
ENSBTAG00000014463
Not yet available
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_198248
CREB phosphorylation through the activation of CaMKII pathway
REACT_230745
Immune System pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_213550
HSF1-dependent transactivation pathway
REACT_224790
Cellular response to heat stress pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_259290
Neuronal System pathway
REACT_258217
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
mmu04740
Olfactory transduction pathway
mmu04012
ErbB signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04114
Oocyte meiosis pathway
mmu04971
Gastric acid secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_120956
Cellular responses to stress pathway
REACT_13685
Neuronal System pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_205580
HSF1-dependent transactivation pathway
REACT_212364
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_226364
Post NMDA receptor activation events pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_212455
Interferon gamma signaling pathway
REACT_206069
Cellular responses to stress pathway
REACT_213138
Immune System pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_209867
CREB phosphorylation through the activation of CaMKII pathway
REACT_216035
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_202705
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_225183
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_218305
CREB phosphorylation through the activation of Ras pathway
REACT_225103
Interferon Signaling pathway
REACT_225032
Neuronal System pathway
REACT_219681
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_225257
Cellular response to heat stress pathway
REACT_214196
Trafficking of AMPA receptors pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04740
Olfactory transduction pathway
hsa04012
ErbB signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa05214
Glioma pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.255822 Mm.397613 Mm.402584 Mm.405366 Mm.411874
RefSeq NM_001025438 NM_001025439 NM_023813 XM_006500821 XM_006500826 XM_006500838
OMIM
CCDS CCDS17823 CCDS38624 CCDS51065
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca