InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POM121

Summary

InnateDB Gene

IDBG-19260.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POM121

Gene Name

POM121 transmembrane nucleoporin

Synonyms

P145; POM121A

Species

Homo sapiens

Ensembl Gene

ENSG00000196313

Encoded Proteins

IDBP-19637

POM121 membrane glycoprotein

IDBP-239892

POM121 membrane glycoprotein

IDBP-377220

POM121 membrane glycoprotein

IDBP-377221

POM121 membrane glycoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and multiple pseudogenes have been identified. [provided by RefSeq, Mar 2012]
This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:72879365-72951440

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000358357	ENSP00000351124
ENST00000395270	ENSP00000378687
ENST00000446813	ENSP00000393020
ENST00000434423	ENSP00000405562

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0051028	mRNA transport
GO:0055085	transmembrane transport